Co-crystal Structure of PERK bound to N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide inhibitor

Co-crystal Structure of PERK bound to N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide inhibitor Descriptor: Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3, N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1H-pyrazole-4-carboxamide, SULFATE ION Authors: Shaffer, P.L, Bellon, S.F, Long, A.M, Chen, H. Deposit date: 2014-12-09 Release date: 2015-02-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK). J.Med.Chem., 58, 2015

蛋白激酶R样内质网激酶（PERK）与N-{5-[(6,7-二甲氧基喹啉-4-基)氧基]吡啶-2-基}-1-甲基-3-氧代-2-苯基-5-(吡啶-4-基)-2,3-二氢-1H-吡唑-4-甲酰胺抑制剂结合的共晶体结构
描述：真核翻译起始因子2α激酶3（Eukaryotic translation initiation factor 2-alpha kinase 3）、真核翻译起始因子2α激酶3（Eukaryotic translation initiation factor 2-alpha kinase 3）、N-{5-[(6,7-二甲氧基喹啉-4-基)氧基]吡啶-2-基}-1-甲基-3-氧代-2-苯基-5-(吡啶-4-基)-2,3-二氢-1H-吡唑-4-甲酰胺、硫酸根离子
作者：Shaffer, P.L.、Bellon, S.F.、Long, A.M.、Chen, H.
沉积日期：2014-12-09
发布日期：2015-02-04
最后修改日期：2023-09-27
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2埃（2 Å）
引用文献：《1H-吡唑-3(2H)-酮类作为强效选择性蛋白激酶R样内质网激酶（Protein Kinase R-like Endoplasmic Reticulum Kinase, PERK）抑制剂的发现》，《药物化学杂志》（Journal of Medicinal Chemistry），第58卷，2015年