Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response. Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response

RNA-sequencing demonstrated Acod1 (Aconitate decarboxylase 1) as one of the top genes induced by air polution particulate matter (PM) in macrophages. We therefore sought to determine the effect of both exogenous itaconate (4-octyl itaconate) and endogenous itaconate on PM-induced inflammation in macrophages through RNA sequencing. Overall design: Transcriptome of WT and Acod1-/- mouse macrophages in duplicates, using Illumina sequencing.