Unlikely genomic linkage between E. cloacae isolates

This study highlights the limitations of core-genome Multi-Locus Sequence Typing in identifying bacterial cross-transmission in healthcare settings, particularly for taxonomically complex species like Enterobacter cloacae, as illustrated by a case of false-positive genomic linkage between two E. cloacae isolates that were revealed to be distinct through further SNP and phylogenetic analyses, emphasizing the need to consider epidemiological context and confirm potential links through high-resolution analyses.