Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)
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Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2) Descriptor: 1,2-ETHANEDIOL, CHECKPOINT KINASE 2, N-[(4-methoxyphenyl)methyl]quinoxaline-6-carboxamide, ... Authors: Silva-Santisteban, M.C, Westwood, I.M, Boxall, K, Brown, N, Peacock, S, McAndrew, C, Barrie, E, Richards, M, Mirza, A, Oliver, A.W, Burke, R, Hoelder, S, Jones, K, Aherne, G.W, Blagg, J, Collins, I, Garrett, M.D, van Montfort, R.L.M. Deposit date: 2012-10-05 Release date: 2013-06-26 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2. Plos One, 8, 2013
基于片段的筛选（Fragment-based screening）发现检查点激酶2（CHK2，checkpoint kinase 2）抑制剂结合的新区域
描述符：1,2-乙二醇（1,2-ETHANEDIOL）、检查点激酶2、N-[(4-甲氧基苯基)甲基]喹喔啉-6-甲酰胺（N-[(4-methoxyphenyl)methyl]quinoxaline-6-carboxamide）……
作者：Silva-Santisteban, M.C、Westwood, I.M、Boxall, K、Brown, N、Peacock, S、McAndrew, C、Barrie, E、Richards, M、Mirza, A、Oliver, A.W、Burke, R、Hoelder, S、Jones, K、Aherne, G.W、Blagg, J、Collins, I、Garrett, M.D、van Montfort, R.L.M
提交日期：2012-10-05
发布日期：2013-06-26
最后修改日期：2023-12-20
实验方法：X射线衍射（X-RAY DIFFRACTION，3.3 Å）
引用文献：基于片段的筛选绘制检查点激酶2 ATP结合位点内的抑制剂相互作用图谱（Fragment-Based Screening Maps Inhibitor Interactions in the ATP-Binding Site of Checkpoint Kinase 2），发表于《公共科学图书馆·综合》（Plos One），2013年，第8卷
创建时间：
2012-10-05
