Selective Akt inhibition by MK-2206 eleminates colorectal cancer-initiating stem cells

ChEBI2016-07-06 更新2026-07-12 收录

结直肠癌靶向治疗

肿瘤干细胞抑制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-70018 数据链接链接失效反馈

官方服务：

资源简介：

Selective Akt inhibition by MK-2206 eleminates colorectal cancer-initiating stem cells

创建时间：

2016-07-06

FLOX + Erbitux. 1. line treatment to patients with metastatic colorectal cancer and wild type K-RAS tumor. A phase II study.

结直肠癌靶向治疗

临床疗效评估

Primary objectives: The main objective to the trial is response rate. Primary endpoint is to evaluate response rate. Secondary endpoints are to evaluate and determine progressionfree survival, time to

NIAID Data Ecosystem80

Study of Bevacizumab Plus Chemotherapy in Patients With Metastatic Colorectal Cancer

生物标志物预测

结直肠癌靶向治疗

This study evaluates the relationship of biomarker expression and efficacy of bevacizumab plus chemotherapy in patients with unresectable/metastatic colorectal cancer. Before the treatment, the invest

NIAID Data Ecosystem60

Phase II study of chemotherapy with Capecitabine/Bevacizumab in elderly patients with advanced and recurrent colorectal cancer

结直肠癌靶向治疗

老年肿瘤疗效评估

Interventions: Capecitabine plus bevacizumab therapy Capecitabine:2,000mg/m2 twice daily (orally, day1 after dinner:day8 after breakfast) Bevacizumab:7.5mg/kg day 1 The treatment is repeated every thr

NIAID Data Ecosystem30

Colorectal Cancer (CRC) Cetuximab Elderly Frail

结直肠癌靶向治疗

老年肿瘤临床试验

OBJECTIVE: The principal objective of the trial is to evaluate whether the addition of cetuximab associated with 5-fluorouracil in elderly patients with KRAS wild type advanced colorectal cancer (CRC)

NIAID Data Ecosystem70

Design and Synthesis of a 2‑Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy

CDK8抑制剂

结直肠癌靶向治疗

CDK8 is a transcriptional cyclin-dependent kinase and considered as a potential target in colon cancer therapeutics. Here, a novel selective CDK8 inhibitor was identified against colon cancer in vivo.

Figshare60

Selective Akt inhibition by MK-2206 eleminates colorectal cancer-initiating stem cells

资源简介：

相关数据集