Analysis of the gut microbiota in mGluR5-Knockout Mice

Group I metabotropic glutamate receptors (mGluRs) are distributed primarily on postsynaptic excitatory synapses and are associated with depression. It is noticeable, however, that the antidepressant-like effect of mGluR5 modulation is inconsistent across studies. In addition, a large number of studies have shown that the gut microbiota and inflammation play a major role in the pathogenesis of depression. Do gut microbiota and inflammation also affect the mGluR5-related mouse model? Here, we attempted to identify the involvement of the gut microbiota and inflammation in mGluR5 knockout(KO) mice, a controversial model linked to depression.