X-ray photon-correlation spectroscopy of nanoparticles in complex biological environments

We propose to perform an XPCS experiment on gold nanoparticles in biological environments. This includes (1) measuring the dynamics of gold nanoparticles in dense protein solutions and (2) in the presence of living cells. This study will help to understand the underlying mechanisms of nanoparticle-based drugs and will pave the way for establishing XPCS as a method in biology and nanobiotechnology.