Regulatory roles of long non-coding RNAs in minipigs revealed by cross-breed and cross-tissue transcriptomic analyses

We investigated the regulatory roles of long non-coding RNAs (lncRNAs) in minipigs by identifying lncRNAs and conducting comparative transcriptomic analyses using RNA-seq data of five tissues (heart, kidney, liver, lung, and spleen) of minipigs (Korean and Bama minipigs) and pigs (Duroc and Landrace). Through these comparative analyses, we identified lncRNAs associated with biological processes linked to the shared traits of minipigs in contrast to pigs. Additionally, we uncovered the gene regulatory mechanisms of lncRNAs specific to each tissue in minipigs and identified various biological pathways influenced by these mechanisms.