Dietary sugar and fat: Links with obesity and related metabolic disorders in mice

Investigation of the effect of specific diets, with a different content in sugar and fat, in promoting obesity and related comorbidities. Mice were fed either a low-sugar, low-fat control diet (CT), a high-sugar diet (HS), a high-fat, high-sugar diet (HF/HS), or a high-fat diet (HF) for 8 weeks. The impact of the different diets on obesity, glucose metabolism, inflammation, and oxidative and ER stress were determined, as well as diet-induced changes in gut microbiota composition and density.