Crystal structure of human IL-17A in complex with Compound 1

Crystal structure of human IL-17A in complex with Compound 1 Descriptor: (3S)-N-[(3-{[(1S)-2-anilino-1-cyclohexyl-2-oxoethyl]carbamoyl}phenyl)methyl]-2,2-dimethylthiomorpholine-3-carboxamide, Interleukin-17A Authors: Armstrong, A.A, Milligan, C.M, Luo, J. Deposit date: 2025-10-01 Release date: 2025-10-15 Last modified: 2025-12-03 Method: X-RAY DIFFRACTION (3.15 Å) Cite: A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library. Acs Med.Chem.Lett., 16, 2025

人白细胞介素-17A（Interleukin-17A, IL-17A）与化合物1结合的晶体结构。标识符：(3S)-N-[(3-{[(1S)-2-苯胺基-1-环己基-2-氧代乙基]氨基甲酰基}苯基)甲基]-2,2-二甲基硫代吗啉-3-甲酰胺。作者：Armstrong, A.A.、Milligan, C.M.、Luo, J.。存放日期：2025-10-01；发布日期：2025-10-15；最后修改日期：2025-12-03。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率3.15埃（Å）。引用文献：《一种源自DNA编码文库（DNA-Encoded Library）的IL-17A新型小分子变构抑制剂》（原文标题：A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library），刊载于《ACS药物化学快报》（ACS Med.Chem.Lett.）2025年第16卷。