Cytotoxic and genotoxic potential of Avobenzone and Octocrylene on human skin fibroblast cells raw data file

This dataset presents the raw data used to prepare charts for the following paper: Evaluation of cytotoxic and genotoxic potential of Avobenzone and Octocrylene on human skin fibroblast cells. In this study, we investigate the cytotoxic and genotoxic effects of the organic UVA filter avobenzone (AVB), and the UVB filter octocrylene (OCT), found alone or in combination in different sunscreen formulations of CCD-1118Sk: human healthy skin fibroblast cells. The data shows the cytotoxic and genetic potential of Avobenzone and Octocrylene alone and in combination. Absorbance was measured using a microplate reader at a wavelength of 450 nm, and cell proliferation curve was drawn. For the XTT assay, after blank subtraction, percent growth inhibition of cells was calculated as follows: Growth inhibition (%)=( 1-Aexp group)/(A control)× 100 . The results of the Comet test were calculated by averaging the data obtained for each dose of each parameter. The intracellular ROS assay results were also calculated by averaging the data obtained for each dose. The graphs are available in the article.本数据集为下述论文的配图制备提供原始实验数据：《阿伏苯宗(Avobenzone)与奥克立林(Octocrylene)对人皮肤成纤维细胞的细胞毒性与遗传毒性潜力评估》。本研究针对两种防晒剂——有机UVA过滤剂阿伏苯宗(AVB)与UVB过滤剂奥克立林(OCT)——单独或按不同防晒配方复配时，对CCD-1118Sk人健康皮肤成纤维细胞的细胞毒性与遗传毒性效应展开探究。本数据集涵盖阿伏苯宗与奥克立林单独及复配使用时的细胞毒性与遗传毒性相关实验数据。实验采用酶标仪在450 nm波长下测定吸光度，并绘制细胞增殖曲线。针对XTT检测法，在扣除空白组吸光度后，细胞生长抑制率按以下公式计算：生长抑制率(%)=(1-A实验组/A对照组)×100。彗星实验(Comet test)的结果通过对各参数在各剂量下获取的实验数据取平均值得到。细胞内活性氧(ROS, Reactive Oxygen Species)检测实验的结果同样通过对各剂量下获取的实验数据取平均值得到。相关图表已收录于该论文中。