Additional file 5 of TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

Additional file 5. Results of RNA-seq Ingenuity Pathways Analysis on TREM2 KO PPI groups. For each PPI group separate files give information about the genes assigned to that group (suffix “_Genes”), the predicted upstream regulators with Activation Z-score indicating whether the change mimics (+) or opposes (−) TREM2 KO transcriptional effects (suffix “_UpstreamAnalysis”), and the relationship of predicted upstream regulators to disease/functions (suffix “_RegulatorEffects”).

附加文件5. 对TREM2敲除型蛋白质相互作用组进行的RNA测序Ingenuity通路分析结果。对于每个蛋白质相互作用组，分别提供关于分配给该组的基因的信息（后缀“_Genes”），预测的上游调控因子及其激活Z分数，用以指示变化是否模拟（+）或相反（−）TREM2敲除型转录效应（后缀“_UpstreamAnalysis”），以及预测的上游调控因子与疾病/功能之间的关系（后缀“_RegulatorEffects”）。