DCP1-DCP2 complex decaps mRNA

The DCP1-DCP2 decapping complex binds the 7-methylguanosine cap of mRNA and hydrolyzes the triphosphate bond to yield 7-methylguanosine 5'-diphosphate and RNA with 5'-monophosphate. The DCP2 subunit of the complex catalyzes the hydrolysis. DCP2 has higher affinity for some subsets of mRNA.

DCP1-DCP2解帽复合物与mRNA的7-甲基鸟苷帽结合，并水解三磷酸键，从而产生7-甲基鸟苷5'-二磷酸和带有5'-单磷酸的RNA。该复合物的DCP2亚基催化水解反应。DCP2对于某些mRNA子集具有较高的亲和力。