Supplementary Material for: Treatment of Chronic-Relapsing Pitted Keratolysis with Glycopyrronium Bromide Cream: case report

Introduction: Pitted keratolysis (PK) is a superficial bacterial infection located almost exclusively on the soles. The most important predisposing factor is hyperhidrosis. PK is characterized by small, isolated or confluent, crateriform, noninflammatory pits. Maceration and malodor are the two most important signs and symptoms. The therapy of PK is very often unsatisfactory. Case Presentation: Two patients with chronic-relapsing PK were successfully treated with a cream containing 1% glycopyrronium bromide, a new topical anticholinergic with anti-hyperhidrosis action. Conclusions: Although our experience is currently based on only two patients, glycopyrronium bromide cream can be taken into consideration for prevention of chronic-relapsing PK.

引言：窝状角质松解症（Pitted keratolysis，PK）是一种几乎仅累及足底的浅表性细菌感染。其最主要的易感因素为多汗症（hyperhidrosis）。该病以细小、孤立或融合的火山口样非炎性凹陷为特征，浸渍与恶臭是两大最为关键的体征与症状。窝状角质松解症的临床治疗往往效果欠佳。
病例报告：2例慢性复发性窝状角质松解症患者，经外用含1%格隆溴铵（glycopyrronium bromide）的乳膏治疗后获得成功治愈；格隆溴铵是一种新型外用抗胆碱能药物，具备抗多汗功效。
结论：尽管目前我们的临床经验仅基于2例患者，但格隆溴铵乳膏可被纳入慢性复发性窝状角质松解症的预防治疗方案考量范围。

搜集汇总

背景与挑战

背景概述

该数据集是医学案例报告的补充材料，聚焦于使用1%格隆溴铵乳膏治疗慢性复发性窝状角化溶解症的两个病例，旨在提供原始数据支持相关研究。数据集发布于2024年，属于医学领域，强调格隆溴铵作为新型局部抗胆碱能药物在预防该疾病复发中的潜在应用，并附有使用指标和开放获取许可证。