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HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response

ChEBI2015-02-13 更新2026-07-21 收录

B细胞免疫应答

mRNA剪切调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-62148 数据链接链接失效反馈

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资源简介：

HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response

应用场景：

创建时间：

2015-02-13

B细胞免疫应答

生发中心转录组学

Germinal centres (GC) are specialized sites where B cells expand and diversify their antibody genes through somatic hypermutation. GC B-cells are routinely identified through distinct changes on their

NIAID Data Ecosystem140

Analysis of germinal centers in UNG and AID deficient mice

B细胞免疫应答

基因缺陷模型

Analyze kinetics, cell composition and proliferation of germinal center B cells in wt vs Ung-/- vs Aicda-/- vs Ung-/- Aicda-/- mice after immunization with model antigens.

NIAID Data Ecosystem80

TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer [H3K27ac_ChIP-seq]. TET enzymes augment AID expression via 5hmC modifications at the Aicda superenhancer [H3K27ac_ChIP-seq]

5hmC表观遗传

B细胞免疫应答

TET enzymes are dioxygenases that promote DNA demethylation by oxidizing the methyl group of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Here we report a close correspondence between 5hm

NIAID Data Ecosystem50

Spleen vs MIP3-alpha Treated B cell. Mus musculus

B细胞免疫应答

基因表达时间序列

total RNA from mouse (male c57BL/6) spleen labeled with Cy3 vs total RNA from mouse (male c57BL/6) B cells treated with MIP3-alpha labeled with Cy5- time course with repeats Keywords: ordered

NIAID Data Ecosystem80

Raw data for Fig 4 in pzfx format.

补体系统免疫

B细胞免疫应答

Francisella tularensis (Ft), a Gram-negative bacterium that causes tularemia, possesses a non-inflammatory atypical LPS (LPSFt) that is highly immunogenic through unknown mechanism. We previously show

Figshare2025-12-17 更新50

HuR- dependent regulation of mRNA splicing is essential for the B cell antibody response

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