MicroRNAs in cardiomyocyte hypertrophy

This pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lines. MicroRNAs are shown as purple rounded rectangles. It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1544 CPTAC Assay Portal]

本路径展示了微小RNA在心脏肥厚过程中的作用。通过TargetScan算法预测了微小RNA的目标，预测的相互作用以红色虚线表示。微小RNA以紫色圆形矩形表示。尚不确定哪些WNT和frizzled蛋白会影响心脏肥厚。尽管有强有力的证据表明WNT3A、WNT5A、frizzled1和frizzled2在心脏肥厚中发挥作用，因此这些蛋白已被添加至路径中，而非所有WNT和frizzled蛋白。正在进行实验以阐明此问题。本路径上的蛋白质可通过[https://assays.cancer.gov/available_assays?wp_id=WP1544 CPTAC检测门户]进行针对性的检测。