Rif1 functions in complex with PRC1.6 to regulate mouse embryonic stem cells fate potential [RNA-seq]

To investigate the cooperative function Rif1 and PRC1.6 complex in the regulation of embryonic development and cell differentiation, we selected embryonic stem cells in which each target gene has been knocked down by shRNA or knocked out conditionally. We then performed gene expression profiling analysis using data obtained from RNA-seq of different samples. Overall design: Comparative gene expression profiling analysis of RNA-seq data for embryonic stem cells and its KD or KO derivatives (Rif1 CKO, shMax, shPcgf6, shRNF2).