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Cardiac Function and Architecture Are Maintained in a Model of Cardiorestricted Overexpression of the Prorenin-Renin Receptor

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Figshare2016-01-18 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_Cardiac_Function_and_Architecture_Are_Maintained_in_a_Model_of_Cardiorestricted_Overexpression_of_the_Prorenin_Renin_Receptor_/944246
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The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. We therefore generated a transgenic mouse (Tg) with cardio-restricted (P)RR overexpression driven by the alpha-MHC promotor. The mRNA expression of (P)RR was ∼170-fold higher (P
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2016-01-18
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