Bilosomal Encapsulation of Binuclear Phosphino Ru(II)−Cu(II) Compounds Enhances Their Selectivity and Activity toward Lung and Prostate Cancers - research data

The dataset accompanying the publication comprises a wide range of experimental and analytical results: Spectroscopic and structural data: NMR, UV-Vis, IR, EPR, emission spectra, cyclic voltammetry, mass spectrometry (ESI-MS), elemental analysis, and X-ray crystallography files. Computational results: Density Functional Theory (DFT) optimized structures provided as .xyz files. Physicochemical stability studies: Spectral monitoring in aqueous media, DMSO, and cell culture medium. Microscopy and imaging: Visual documentation of bilosomal encapsulation of Ru(II)-Cu(II) complexes.
Biological assays: IC50 values for multiple cancer cell lines (lung, breast, pancreatic, prostate) and noncancerous controls. Mechanistic studies (ROS generation, lipid peroxidation, mitochondrial depolarization, apoptosis markers). In vivo toxicity tests using zebrafish (Danio rerio) larvae. 3D cancer spheroid model experiments with bilosome-encapsulated complexes. File types included: spectral plots, crystallographic data tables, DFT structure files, microscopy images, IC50 tables, and toxicity assay results.