Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59
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Crystal structure of unliganded CH59UA, the inferred unmutated ancestor of the RV144 anti-HIV antibody lineage producing CH59 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CH59UA Fab fragment of heavy chain, CHLORIDE ION, ... Authors: Wiehe, K, Easterhoff, D, Luo, K, Nicely, N.I, Bradley, T, Jaeger, F.H, Dennison, S.M, Zhang, R, Lloyd, K.E, Stolarchuk, C, Parks, R, Sutherland, L.L, Scearce, R.M, Morris, L, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, Rerks-Ngarm, S, Michael, N, Kim, J, Kelsoe, G, Montefiori, D.C, Tomaras, G, Bonsignori, M, Santra, S, Kepler, T.B, Alam, S.M, Moody, M.A, Liao, H.-X, Haynes, B.F. Deposit date: 2014-05-19 Release date: 2015-02-18 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Antibody Light-Chain-Restricted Recognition of the Site of Immune Pressure in the RV144 HIV-1 Vaccine Trial Is Phylogenetically Conserved. Immunity, 41, 2014
未配体结合的CH59UA晶体结构:对应产生CH59的RV144抗HIV抗体谱系的推定未突变祖先
组分描述:2-(N-吗啉代)乙磺酸、CH59UA重链Fab片段、氯离子……
作者:Wiehe K、Easterhoff D、Luo K、Nicely N.I、Bradley T、Jaeger F.H、Dennison S.M、Zhang R、Lloyd K.E、Stolarchuk C、Parks R、Sutherland L.L、Scearce R.M、Morris L、Kaewkungwal J、Nitayaphan S、Pitisuttithum P、Rerks-Ngarm S、Michael N、Kim J、Kelsoe G、Montefiori D.C、Tomaras G、Bonsignori M、Santra S、Kepler T.B、Alam S.M、Moody M.A、Liao H.-X、Haynes B.F
保藏日期:2014年5月19日
发布日期:2015年2月18日
最后修改日期:2024年11月6日
实验方法:X射线衍射(分辨率2.4埃)
引用文献:《抗体轻链限制性识别RV144 HIV-1疫苗试验中的免疫压力位点具有系统发育保守性》,《免疫学(Immunity)》,第41卷,2014年
创建时间:
2014-05-19



