Gene expression changes in <i>Nipbl<sup>+/−</sup></i> mouse limb buds.
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Relative gene expression levels in limb buds of stage-matched, E10.5 wildtype and Nipbl+/− mice were determined as described (see Materials and Methods), and in certain cases confirmed by Q-RT-PCR. Selected transcripts are shown. iInvolved in control of Shh expression in limb bud [101]. iiAlso controls Hox gene expression in the limb bud [102]. iiiAlso controls Hox gene expression in the limb bud [69]. ivDirect target of Hoxd13 in limb buds [103]. vDirects the position of the Shh expression boundary delineating the experimentally defined ZPA [104]. viMesenchymal, involved in chondrocyte proliferation [105]. viiAER-Fgf[106]. viiiStrongly activated by HOXA13 [67]. ixHOXA13 target in limb buds [68]. xFunctions as a HOX cofactor during development; complexes with HOXA9; also controls Hox and Shh expression [102]. xiNon-canonical Wnt [107]. xiiCanonical Wnt [108]. xiiiInteracts with some Wnts and Frizzleds and supports Wnt-Fz-Ror2 complex formation, and at the same reduces Wnt-Fz-LRP complex formation, thus favoring non-canonical Wnt signaling [109]. xivWnt regulator; required for maintenance of AER and Shh signaling [110]. Gene expression changes in Nipbl+/− mouse limb buds.
