ROLE OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN THE DEVELOPMENT OF HYPERTENSION ON THE BACKGROUND OF OBESITY

Obesity is a major global health problem and a key risk factor for arterial hypertension. The renin-angiotensin-aldosterone system (RAAS) plays a central role in blood pressure regulation, and its dysregulation in obesity contributes to the development and progression of hypertension. Excess visceral adipose tissue increases RAAS activity, leading to elevated angiotensin II and aldosterone levels, vasoconstriction, sodium and water retention, and endothelial dysfunction. Understanding the pathophysiological mechanisms linking obesity and RAAS is essential for designing effective preventive and therapeutic strategies. Early identification and targeted modulation of RAAS activity can improve cardiovascular outcomes in obese hypertensive patients. This study highlights the significance of RAAS in obesity-related hypertension and the importance of integrated lifestyle and pharmacological interventions.