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TMPyP4 promotes cancer cell migration at low dose, but induces cell death at high dose

ChEBI2015-09-14 更新2026-07-12 收录

抗癌药物筛选

细胞迁移与死亡

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-72983 数据链接链接失效反馈

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TMPyP4 promotes cancer cell migration at low dose, but induces cell death at high dose

应用场景：

创建时间：

2015-09-14

PARP-1靶向药物发现

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Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective

NIAID Data Ecosystem50

NCI60 Transcriptome

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癌细胞分析

MRNA sequencing of the NCI60 cell lines

NIAID Data Ecosystem40

Thiazolation of phenylthiosemicarbazone to access new thiazoles: anticancer activity and molecular docking

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分子对接

Aim: Novel thiazole hybrids were synthesized via thiazolation of 4-phenylthiosemicarbazone (4). Materials & methods: The anticancer activity against the NCI 60 cancer cell line panel. Results: Methyl

NIAID Data Ecosystem10

Discovery of Quinazoline-2,4(1 H ,3 H )‑dione Derivatives Containing 3‑Substituted Piperizines as Potent PARP-1/2 InhibitorsDesign, Synthesis, In Vivo Antitumor Activity, and X‑ray Crystal Structure Analysis

PARP抑制剂研发

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Inhibiting PARP-1/2 offered an important arsenal for cancer treatments via interfering with DNA repair of cancer cells. Novel PARP-1/2 inhibitors were designed by capitalizing on methyl- or ethyl-subs

NIAID Data Ecosystem50

Transcriptome data of cancerous (HCT-116) and non-cancerous (IPEC-J2) intestinal cells treated with curcumin analogues

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转录组分析

This dataset contains RNA sequencing data of cancerous HCT-116 and non-cancerous intestinal IPEC-J2 cells treated with curcumin, three curcumin-based benzothiazepane analogues, and untreated controls.

NIAID Data Ecosystem10

TMPyP4 promotes cancer cell migration at low dose, but induces cell death at high dose

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