Transcriptomic Analysis of Identical Twins with Different Onset Ages of ALD

Adrenoleukodystrophy (ALD) is a rare X-linked neurogenetic disease caused by mutations in the ABCD1 gene. Currently, the molecular mechanisms underlying the onset and severity of ALD still remain unclear. For mining information on candidate genes associated with onset and severity of ALD, RNA-seq had been executed via using whole blood samples from monozygotic twin families with ALD disease. The information on candidate genes of this research had been considered as the crucial for preliminarily exploring the molecular mechanisms relating to the onset and severity of ALD, which offered novel insights and research directions for mitigating and treating the development of ALD. To invesigate the onset and severity of ALD in identical twins, eight whole blood samples from monozygotic twin families with ALD disease had used to divided into five groups according to phenotype. Then, the relevant candidate genes were mined by comparison between different groups.