Pregnancies with extreme fetal-maternal HLA incompatibility

Pregnancy requires local immune tolerization. Oocyte donation (OD) pregnancies, with extensive fetal-maternal HLA mismatching, are at higher risk of pre-eclampsia. We hypothesize that immune adaptations are needed at the fetal-maternal interface to maintain healthy pregnancy despite high HLA dissimilarity. This study is by X. Tian et al. The data sets concern raw HLA genotyping data, imaging mass cytometry data and RNA sequencing data generated from decidua basalis of fully-allogeneic healthy pregnancies, semi-allogeneic healthy pregnancies, and fully-allogeneic pregnancies with pre-eclampsia.