Crystal structure of Reverb alpha in complex with synthetic agonist

Crystal structure of Reverb alpha in complex with synthetic agonist Descriptor: (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine, Nuclear receptor corepressor 1, Nuclear receptor subfamily 1 group D member 1 Authors: Ronin, C, Ciesielski, F, Hegazy, L, Burris, P.T. Deposit date: 2022-06-08 Release date: 2022-12-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.504 Å) Cite: Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 13, 2022REV-ERBα（Reverb alpha）与合成激动剂（描述符：(4S)-6-[[1,1'-联苯]-2-基]氧基]-3-氯[1,2,4]三唑并[4,3-b]哒嗪）、核受体辅阻遏蛋白1（Nuclear receptor corepressor 1）及核受体亚家族1组D成员1（Nuclear receptor subfamily 1 group D member 1）结合的晶体结构 作者：Ronin, C、Ciesielski, F、Hegazy, L、Burris, P.T. 提交日期：2022-06-08 发布日期：2022-12-14 最后修改日期：2024-04-03 检测方法：X射线衍射（分辨率2.504埃） 引用文献：核受体REV-ERB合成激动剂激活的结构基础. 《自然·通讯》, 13卷, 2022