Targeted Temperature Management for Poor grade Aneurysmal Subarachnoid Hemorrhage: A pilot study

Sixty patients (30 treated with TTM and 30 with standard treatment) were included in the study. At three months, a favorable prognosis (mRS score 0 to 3) was significantly higher in the TTM group than in the control group (n=14, 46.7% vs. n=6, 20.0%, P=0.028). Multivariate logistics regression analysis indicated that TTM (OR=0.160, 95%CI:0.038-0.682, P=0.013) reduced the number of unfavorable prognoses three months after admission. This study demonstrated the effectiveness and safety of TTM in pa-tients with poor-grade aSAH, and its implementation improved neurological outcomes. Multicenter ran-domized controlled studies with a large number of patients are needed to confirm these observations.