Meta-regression analysis with cancer detection rate of each strategy as the primary outcome, adjusting for mean age, mean PSA, and mean number of previous biopsies.

TS-B is shown as the reference category for the purpose of comparison with the other two strategies. (TP-B – Transperineal biopsy, TS-B –Transrectal saturation biopsy, MRI-B – MRI guided biopsy).