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Hydrazonyl Radical-Participated Tandem Reaction: A Strategy for the Synthesis of Pyrazoline-Functionalized Oxindoles

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Figshare2016-02-12 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Hydrazonyl_Radical_Participated_Tandem_Reaction_A_Strategy_for_the_Synthesis_of_Pyrazoline_Functionalized_Oxindoles/2097625
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An efficient and practical tandem cyclization/addition/cyclization strategy is developed for the initial generated hydrazonyl radicals derived from the oxidation of β,γ-unsaturated hydrazones. By using this protocol, structurally novel pyrazoline-functionalized oxindoles are prepared by the reaction of easily accessible β,γ-unsaturated hydrazones with N-aryl acrylamides under the metal- and solvent-free conditions of DTBP (di-tert-butyl peroxide) via a tandem intra/intermolecular C–N/C–C/C–C bond formation.
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2016-02-12
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