Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer

Breast cancer (BRCA) has become the most common type of cancer in women. Improving the therapeutic response remains a challenge. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a classic tumour suppressor with emerging new functions discovered in recent years, and myeloid PTEN loss has been reported to impair antitumour immunity. In this study, we revealed a novel mechanism by which myeloid PTEN potentially affects antitumour immunity in BRCA. We detected accelerated stress granule (SG) assembly under oxidative stress in PTEN-deficient bone marrow-derived macrophages (BMDMs) through the EGR1-promoted upregulation of TIAL1 transcription. PI3K/AKT/mTOR (PAM) pathway activation also promoted SG formation. ATP consumption during SG assembly in BMDMs impaired the phagocytic ability of 4T1 cells, potentially contributing to the disruption of antitumour immunity. In a BRCA neoadjuvant cohort, we observed a poorer response in myeloid PTENlow patients with G3BP1 aggregating a..., Here we submitted the original data of Detailed information, including the patient number, MP grade, and MOD of specific targets which  is summarized in Supplementary Table 2; the screened transcription factors among the DEGs between Ptenf/f and Ptenmko BMDMs as Supplementary Table 3; the jVenn results of 6 potential transcription factors of TIAL1 as Supplementary Table 4 and the potential binding sites of TIAL1 using JASPAR software as Supplementary Table 5., , # Myeloid PTEN loss affects the therapeutic response by promoting stress granule assembly and impairing phagocytosis by macrophages in breast cancer

([https://doi.org/10.5061/dryad.djh9w0w82 ](https://doi.org/10.5061/dryad.djh9w0w82))

This is the resource data of Supplementary table 2,3,4,5. 

*(N/A)*: Not Applicable. Empty cells which have no data to display or there's no specific value for the cell.

## Description of the data and file structure

**Supplementary Table 2**. is a summarization of detailed information, including the patient number, MP grade, and MOD of specific targets.

*No*: serial number of specimens

*H*: high

*L*: low

n: number of specimens

**Supplementary Table 3** was the results of  all the transcription factors screened out from the DEGs between *Pten*f/f and *Pten*mko BMDMs.

*TF:* transcription fa...