Baseline Clinical Characteristics of SOS Study Participants Stratified by PNPLA3 I148M Genotype.

Abbreviations: SOS, Swedish obese subjects; PNPLA3, patatin-like phospholipase domain-containing 3; II, individuals with two 148I alleles; MM, individuals with two 148M alleles; IM, heterozygotes; n, number; HOMA-IR, homeostasis model assessment for insulin resistance; HDL, high-density lipoprotein; AST, aspartate transferase; ALT, alanine transferase.Plus-minus values are means ± SD.*P values were calculated using linear regression model including age, gender and body-mass index for all variables. HOMA-IR, triglycerides, ALT and AST were log-transformed before entering the model. Male gender, lipid-lowering medications and type 2 diabetes distribution were compared by χ2 test. See methods for more details on the statistical analyses.†Fasting insulin and HOMA-IR are shown only in non-diabetic individuals.