LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria

LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria Descriptor: (2S,4S)-N-[(3R,5R)-1-cyclopropylcarbonyl-5-[[[4-[2-[4-[(1S)-2-methoxy-1-oxidanyl-ethyl]phenyl]ethynyl]phenyl]carbonylamino]methyl]pyrrolidin-3-yl]-4-fluoranyl-pyrrolidine-2-carboxamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION Authors: Ryan, M.D, Pallin, T.D, Lamers, M.B.A.C, Leonard, P.M. Deposit date: 2021-10-13 Release date: 2022-11-02 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.92 Å) Cite: LpxC Inhibitors With Fluoroproline As A Novel Zinc-Binding Group Can Serve As A Novel Class of Antibiotic With Activity Against Multidrug-Resistant Gram-Negative Bacteria To Be Published

以氟脯氨酸作为新型锌结合基团（zinc-binding group）的LpxC抑制剂可作为一类新型抗生素，对多重耐药革兰氏阴性菌（Gram-Negative Bacteria）具有抗菌活性
描述项：(2S,4S)-N-[(3R,5R)-1-环丙基羰基-5-[[[4-[2-[4-[(1S)-2-甲氧基-1-羟乙基]苯基]乙炔基]苯基]羰基氨基]甲基]吡咯烷-3-基]-4-氟-吡咯烷-2-甲酰胺，UDP-3-O-酰基-N-乙酰葡糖胺脱乙酰酶（UDP-3-O-acyl-N-acetylglucosamine deacetylase），锌离子（ZINC ION）
作者：Ryan, M.D、Pallin, T.D、Lamers, M.B.A.C、Leonard, P.M.
提交日期：2021-10-13
发布日期：2022-11-02
最后修改日期：2024-01-31
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.92埃（Å）
引用文献：《以氟脯氨酸作为新型锌结合基团的LpxC抑制剂可作为一类新型抗生素，对多重耐药革兰氏阴性菌具有抗菌活性》（待发表）