The canonical pathways that were most affected in nonagenarians of both genders.

P-values were derived from Fisher’s exact test, -log(0.05) = 1.3, and the Benjamini-Hochberg-corrected t-test (FDR), –log(0.25) = 0.61. The ratio is the number of differentially expressed genes in the data set divided by the total number of genes in the given pathway. The rank indicates the position of the pathway in the gender-specific pathway list. A complete list of the pathways affected in both genders is shown in supplementary Table S3.