Genome-wide expression of mRNAs and microRNAs in response to ERI2 knockdown. Homo sapiens

Here we describe the biological properties of new member of the Enhancer of RNAi (ERI) subfamily of DEDDh nucleases in humans, called ERI-2 that is important for miRNA processing and decay for a large subset of eukaryotic miRNA transcripts. hERI-2 is a potent Mg2+ dependent 3’-5’ exoribonuclease that also regulates the cell cycle and is a negative regulator of RISC. Overall design: miRNA-seq and RNA-seq in ERI2 KD and control samples