Selected amino acid variants of papain-like protease from SARS-CoV-2.

Frequent mutations are those with mutation rate >0.002. Residues from inhibitor binding site were selected based on residue-ligand distance (no more than 6 Å) calculated for all available PLpro-ligand crystal structures. Amino acids in Variants column are sorted from most to least frequent. All found variants are available in Supplementary Material.