Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-dichloro methylene triphosphate

Ternary complex of DNA polymerase beta with a dideoxy terminated primer and 2'-deoxyguanosine 5'-beta, gamma-dichloro methylene triphosphate Descriptor: 2'-deoxy-5'-O-[(S)-{[(R)-[dichloro(phosphono)methyl](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', ... Authors: Batra, V.K, Upton, J, Kashmerov, B, Beard, W.A, Wilson, S.H, Goodman, M.F, McKenna, C.E. Deposit date: 2009-09-04 Release date: 2010-06-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues. J.Am.Chem.Soc., 132, 2010

DNA聚合酶β与双脱氧终止引物以及2'-脱氧鸟苷5'-β,γ-二氯亚甲基三磷酸的三元复合物
描述符：2'-脱氧-5'-O-[(S)-{[(R)-[二氯(膦酰基)甲基](羟基)膦酰基]氧基}(羟基)膦酰基]鸟苷，5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'，5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'，……
作者：Batra, V.K.、Upton, J.、Kashmerov, B.、Beard, W.A.、Wilson, S.H.、Goodman, M.F.、McKenna, C.E.
存入日期：2009-09-04
发布日期：2010-06-02
最后修改日期：2023-09-06
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.15埃（Å）
引用文献：《卤代β,γ-亚甲基-和亚乙基-dGTP-DNA与DNA聚合酶β的三元复合物：氟代亚甲基类似物立体特异性结合的结构证据》，《美国化学会志》（J.Am.Chem.Soc.），132卷，2010年