Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone

Crystal structure of rabbit muscle glycogen phosphorylase in complex with 3,4-dihydro-2-quinolone Descriptor: (5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, (S)-2-CHLORO-N-(1-(2-(2-HYDROXYETHYLAMINO)-2-OXOETHYL)-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-3-YL)-6H-THIENO[2,3-B]PYRROLE-5-CARBOXAMIDE, Glycogen phosphorylase, ... Authors: Birch, A.M, Kenny, P.W, Oikonomakos, N.G, Otterbein, L, Schofield, P, Whittamore, P.R.O, Whalley, D.P, Rowsell, S, Pauptit, R, Pannifer, A, Breed, J, Minshull, C. Deposit date: 2006-09-19 Release date: 2006-12-26 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors. Bioorg.Med.Chem.Lett., 17, 2007

兔肌肉糖原磷酸化酶（glycogen phosphorylase）与3,4-二氢-2-喹诺酮（3,4-dihydro-2-quinolone）复合物的晶体结构
描述项：(5-羟基-4,6-二甲基吡啶-3-基)甲基二氢磷酸酯、(S)-2-氯-N-(1-(2-(2-羟乙基氨基)-2-氧代乙基)-2-氧代-1,2,3,4-四氢喹啉-3-基)-6H-噻吩并[2,3-b]吡咯-5-甲酰胺、糖原磷酸化酶等
作者：Birch, A.M.、Kenny, P.W.、Oikonomakos, N.G.、Otterbein, L.、Schofield, P.、Whittamore, P.R.O.、Whalley, D.P.、Rowsell, S.、Pauptit, R.、Pannifer, A.、Breed, J.、Minshull, C.
提交日期：2006-09-19
发布日期：2006-12-26
最后修改日期：2024-11-20
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.91埃（Å）
引用文献：《强效口服活性1-取代-3,4-二氢-2-喹诺酮类糖原磷酸化酶抑制剂的开发》，《Bioorg.Med.Chem.Lett.》2007年第17卷