Deficiency of Sox7 Leads to Congenital Aortic Stenosis via Abnormal Valve Remodeling

Figure 1. Expression patterns of Sox7 in mammalian hearts. Figure 2. The changes in cardiac function of Nfatc1 Cre;Sox7fl/fl mice. Figure 3. Deficiency of Sox7 in endocardium leads to congenital aortic stenosis. Figure 4. The alteration of the proliferation and apoptosis level in the valve in Nfatc1 Cre;Sox7fl/fl mice. Figure 5. The underlying mechanism of congenital aortic stenosis caused by Sox7 deficiency in endocardium. Figure 6. Sox7 up-regulate MMP9 and has an effect on the proliferation and apoptosis of VICs. Figure 7. The changes of multiple genes in the proliferation and apoptosis of VICs and the expression levels of Sox7 protein in the human fetal aortic valve.