the role of HPV11 E7 in modulating sting-dependent interferon β response in recurrent respiratory papillomatosis

recurrent respiratory papillomatosis is a rare benign tumor caused mainly by the infection of the respiratory tract epithelial cells by the human papillamavirus type 6/11.the specific mechanisms underlying the inhibition of the host's innate immune response by HPV remian unclear.For this purpose,we employed single cell RNA sequencing to analyze the states of various immune cells in RRP samples post HPV infection. four papilloma and three normal muscosal samples were subjected to transcriptome profiling by single cell RNAsequencing