Independent validation of human CD4+ T-cell transcriptome in early arthritis

An exploration of the peripheral blood CD4+ T-cell transcriptome of early arthritis clinic attendees, (i) to provide validation of previously published observations, and (ii) to facilitate an eQTL analysis. Ex-vivo CD4+ T-cell RNA was obtained following first early arthritis clinic attendance from 178 patients. Four diagnostic categories were confirmed at median 28 months follow-up. The key outcome categories are RA and non-RA. The complete dataset representing 71 re-analyzed samples (from GSE20098) and 178 new samples. [1] The 'Gene_Expression_Raw_DetP.txt' contains raw data for all 249 samples, [2] the 'normalized_re-analysis.txt' contain re-analyzed normalized data for the GSE20098 samples, [3] the complete metadata is provided as metadata_all.xls.