RNA-sequencing reveals a distinct transcriptomic signature of chicken embryonic stem cells (cESC) infected with recombinant vaccine vectors

In this study, we used RNA-sequencing to compare the transcriptional programmes in cESC, elicited either by stimulation with recombinant interferon-α or by infection with the attenuated Fowlpox virus vaccine strain (FP9), the canarypox virus vaccine strain (CNPV), the Modified Vaccinia Ankara (MVA) virus or PBG98, a mild vaccine strain of infectious bursal disease virus. Examination of the transcriptome of cESC following stimulation with recombinant IFN-a or infection with recombinant vaccine viral vectors (Fowlpox virus FP9, MVA, Canarypox virus CNPV, Infectious bursal disease virus PBG98)