Table_1_Disrupted Regional Homogeneity in Drug-Naive Patients With Bipolar Disorder.docx

ObjectiveStudies on alterations in the regional neural activity in the brain of patients with bipolar disorder (BD) have provided conflicting results because of different medications used and study designs. A low bone mineral density (BMD) is also observed in patients with BD. This study aimed to further explore regional neural activities in unmedicated patients with BD and their association with BMD.MethodsIn this study, 40 patients with BD and 42 healthy controls were scanned through resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo) and pattern classification. Pearson’s correlation analyses were performed to explore the correlations between abnormal ReHo and BMD.ResultsA significant increase in ReHo values in the left inferior frontal gyrus (IFG)/temporal pole, left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem, and right superior temporal gyrus (STG) and a decrease in ReHo in the occipital gyrus (OG; left middle OG/superior OG/bilateral cuneus) were found in the patients with BD (p < 0.05) compared with those in the healthy controls. No significant correlation was observed between the abnormal ReHo values in any of the brain regions of the patients with BMD.Support vector machine (SVM) analyses revealed that the ReHo values in the right STG for distinguishing patients from healthy controls showed an accuracy of 91.89%, a sensitivity of 75.68%, and a specificity of 83.78%. The ReHo values in the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem indicated an accuracy of 78.38%, a sensitivity of 75.68%, and a specificity of 81.08%.ConclusionThis study further confirms the abnormal brain activities in extensive regions, and these brain regions are primarily located in the fronto–temporal–occipital circuit and the cerebellum vermis of patients with BD. The regional neural activity in the right STG and the left cerebellum vermis I/vermis II/parahippocampal gyrus/brainstem may serve as potential imaging markers to distinguish patients with BD from healthy controls.

针对双相情感障碍（BD）患者大脑区域神经活动变化的客观研究因所用药物及研究设计的差异，结果存在矛盾。在BD患者中亦观察到低骨矿密度（BMD）现象。本研究旨在进一步探究未经药物治疗的双相情感障碍患者的区域神经活动及其与BMD的关联。方法：在本研究中，对40名双相情感障碍患者和42名健康对照者进行了静息态功能性磁共振成像（fMRI）扫描。通过区域一致性（ReHo）和模式分类对成像数据进行分析。通过皮尔逊相关分析，探究异常ReHo与BMD之间的相关性。结果：与健康对照组相比，双相情感障碍患者左侧额下回/颞极、左侧小脑蚓部I/蚓部II/颞角/脑干和右侧颞上回（STG）的ReHo值显著增加（p < 0.05），而枕叶回（OG；左侧中枕回/上枕回/两侧楔叶）的ReHo值则显著降低。在患者BMD的任何脑区中，均未观察到异常ReHo值与BMD之间的显著相关性。支持向量机（SVM）分析显示，右侧STG的ReHo值在区分患者与健康对照者时的准确率为91.89%，灵敏度为75.68%，特异性为83.78%。左侧小脑蚓部I/蚓部II/颞角/脑干的ReHo值表明，其准确率为78.38%，灵敏度为75.68%，特异性为81.08%。结论：本研究进一步证实了广泛脑区的异常脑活动，这些脑区主要位于患者的额叶-颞叶-枕叶环路和小脑蚓部。右侧STG和左侧小脑蚓部I/蚓部II/颞角/脑干的区域神经活动可能作为区分双相情感障碍患者与健康对照者的潜在影像学标记。