Stable Polymorph of Venlafaxine Hydrochloride by Solid-to-Solid Phase Transition at High Temperature
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https://figshare.com/articles/dataset/Stable_Polymorph_of_Venlafaxine_Hydrochloride_by_Solid_to_Solid_Phase_Transition_at_High_Temperature/3019960
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资源简介：
A novel polymorph of the antidepressant drug venlafaxine hydrochloride (VenHCl) was visualized in thermal microscopy
and identified by variable-temperature powder X-ray diffraction at 180−190 °C. Its single-crystal X-ray structure was solved and refined
satisfactorily in P21/n space group (form 6, Z‘ = 2, T = 100 K, R1 = 0.1073). The powder X-ray diffraction pattern and melting point of
form 6 are significantly different from the known polymorphs 1−5. Form 6 has a higher melting point and is more stable than marketed
drug forms 1 and 2.
创建时间：
2016-02-29
