官方服务:
资源简介:
LC-MS/MS analysis of cell lines with induced resistance to BRAF inhibitors
应用场景:
创建时间:
2018-10-19
相关数据集
Gene expression profiling of oncogenic NRAS driven mouse melanomas that have developed resistance to NRAS withdrawal. Mus musculus
Targeted therapies have the potential to revolutionize cancer care by providing personalized treatment strategies that are less toxic and more effective but it is clear that for most solid tumors supp
NIAID Data Ecosystem70
Proteomics identifies markers of MAPKi resistance offering new therapeutic strategies in melanoma- Cytoplasmic (cyt), nuclear (ne) and secreted (sn) proteins of MAPKi sensitive melanoma cells
MAPK inhibitors (MAPKi) show outstanding clinical response rates in melanoma patients harbouring BRAF mutations, but resistance is common. High-throughput, subcellular proteome analyses at two differe
NIAID Data Ecosystem60
RNA-seq melanoma. Homo sapiens
Using a chromatin regulator-focused shRNA library, we found that suppression of sex determining region Y-box 10 (SOX10) in melanoma causes resistance to BRAF and MEK inhibitors. To investigate how SOX
NIAID Data Ecosystem40
New role of ID3 in melanoma adaptive drug-resistance
Adaptive resistance to targeted therapy such as BRAF inhibitors represents in melanoma a major drawback to this otherwise powerful treatment. Some of the underlying molecular mechanisms have recently
NIAID Data Ecosystem60
Acetylcytidine modification of DDX41 and ZNF746 by N-acetyltransferase 10 contributes to chemoresistance of melanoma
We performed RNA-seq to analyse the different expression genes of DTIC-resistant (DR) A375 cells and wild-type control. Examination of differentially expressed genes in DR A375 cells compared with wil
NIAID Data Ecosystem50



