Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor

Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor Descriptor: 4-({4-chloro-6-[(2-hydroxyethyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... Authors: Avvaru, B.S, Wagner, J, Robbins, A.H, Mckenna, R. Deposit date: 2010-04-19 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorg.Med.Chem., 19, 2011

人类碳酸酐酶II（human carbonic anhydrase II）与1,3,5-三嗪（1,3,5-triazine）取代苯磺酰胺（benzenesulfonamide）类抑制剂结合的晶体结构。配体标识符：4-({4-氯-6-[(2-羟乙基)氨基]-1,3,5-三嗪-2-基}氨基)苯磺酰胺、碳酸酐酶2（Carbonic anhydrase 2）、甘油（GLYCEROL）等。作者：Avvaru B.S.、Wagner J.、Robbins A.H.、Mckenna R.。提交日期：2010-04-19；发布日期：2011-04-20；最后修改日期：2023-09-06。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.5 Å）。引用文献：含1,3,5-三嗪基团的磺酰胺类化合物相较于胞质型同工酶I和II，可选择性强效抑制跨膜型碳酸酐酶同工酶IX、XII与XIV：溶液法与X射线晶体学研究。《Bioorg.Med.Chem.》，19卷，2011年