An Enantioselective Total Synthesis and Stereochemical Revision of (+)-Citrinadin B

This
manuscript describes an enantioselective synthesis of the
naturally occurring alkaloid citrinadin B. The synthetic effort revealed
an anomaly in the original structural assignment that has led to the
proposal of a stereochemical revision. This revision is consistent
with the structures previously reported for a closely related family
of alkaloids, PF1270A–C. The synthesis is convergent and employs
a stereoselective intermolecular nitrone cyloaddition reaction as
a key step.