X-ray structure of human PPARgamma ligand binding domain-saroglitazar co-crystals obtained by co-crystallization

X-ray structure of human PPARgamma ligand binding domain-saroglitazar co-crystals obtained by co-crystallization Descriptor: (2S)-2-ethoxy-3-[4-[2-[2-methyl-5-(4-methylsulfanylphenyl)pyrrol-1-yl]ethoxy]phenyl]propanoic acid, Isoform 2 of Peroxisome proliferator-activated receptor gamma Authors: Kamata, S, Honda, A, Uchii, K, Machida, Y, Oyama, T, Ishii, I. Deposit date: 2021-01-27 Release date: 2021-09-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.771 Å) Cite: Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR alpha / gamma Dual Agonist. Biol.Pharm.Bull., 44, 2021

通过共结晶法获得的人类过氧化物酶体增殖物激活受体γ（Peroxisome proliferator-activated receptor gamma, PPARγ）配体结合域与萨拉格列扎（saroglitazar）共晶体的X射线结构。
描述符：(2S)-2-乙氧基-3-[4-[2-[2-甲基-5-(4-甲硫基苯基)吡咯-1-基]乙氧基]苯基]丙酸，对应过氧化物酶体增殖物激活受体γ亚型2。
作者：Kamata, S、Honda, A、Uchii, K、Machida, Y、Oyama, T、Ishii, I
沉积日期：2021-01-27
发布日期：2021-09-08
最后修改日期：2023-11-29
实验方法：X射线衍射（分辨率1.771埃）
引用文献：《作为PPARα/γ双激动剂的抗非酒精性脂肪性肝病及糖尿病性血脂异常药物萨拉格列扎的结构基础》，《生物药学通报（Biol.Pharm.Bull.）》，第44卷，2021年