Data from: Alterations of gray and white matter networks in patients with obsessive-compulsive disorder: a multimodal fusion analysis of structural MRI and DTI using mCCA+jICA

Many of previous neuroimaging studies on neuronal structures in patients
with obsessive-compulsive disorder (OCD) used univariate statistical tests
on unimodal imaging measurements. Although the univariate methods revealed
important aberrance of local morphometry in OCD patients, the covariance
structure of the anatomical alterations remains unclear. Motivated by
recent developments of multivariate techniques in the neuroimaging field,
we applied a fusion method called “mCCA+jICA” on multimodal structural
data of T1-weighted magnetic resonance imaging (MRI) and diffusion tensor
imaging (DTI) of 30 unmedicated patients with OCD and 34 healthy controls.
Amongst six highly correlated multimodal networks (p < 0.0001), we
found significant alterations of the interrelated gray and white matter
networks over occipital and parietal cortices, frontal interhemispheric
connections and cerebella (False Discovery Rate q ≤ 0.05). In addition, we
found white matter networks around basal ganglia that correlated with a
subdimension of OC symptoms, namely ‘harm/checking’ (q ≤ 0.05). The
present study not only agrees with the previous unimodal findings of OCD,
but also quantifies the association of the altered networks across imaging
modalities.