Subcellular locations of top- and bottom- ranked proteins from the 2,249 protein database that have both feedback and non-feedback pathway proteinsa.

aThe 2,249 protein database [13] analyzed contains both feedback and non-feedback pathway proteins.bProtein location based on http://www.uniprot.org/. Each protein can be in more than one location. Each ranked position group (top 50 or bottom 50) contains 50 proteins that their subcellular locations can be identified or suggested by the UniProt database. In case 1 or 2 proteins lack the subcellular location information, the proteins at the 51st and 52ed positions were used as replacements.cThe ChiTEST was between forward ranking and reverse ranking. The top/bottom ratio of protein numbers of the reverse ranking was tested using the top/bottom ratio of forwardly ranked proteins as the reference ratio.*Significant.**Highly significant. NS: Non-significant.