p53 pathway

p53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cycle and thus functions as a tumor suppressor that is involved in preventing cancer. As such, p53 has been described as "the guardian of the genome," "the guardian angel gene," and the "master watchman," referring to its role in conserving stability by preventing genome mutation.

p53，亦称蛋白53或肿瘤蛋白53，是一种转录因子，在人类中由TP53基因编码。在多细胞生物中，p53扮演着至关重要的角色，它调控细胞周期，从而作为肿瘤抑制因子参与癌症的预防。因此，p53被誉为‘基因组守护者’、‘守护天使基因’以及‘总巡警’，这些称谓皆彰显了其在维护基因组稳定性、预防基因突变方面的关键作用。